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The Blob class provides several methods for consuming its contents in different formats. Use .bytes() to read the contents as a Uint8Array.
const blob = new Blob(["hello world"]);
const arr = await blob.bytes();
Alternatively, read the contents into an ArrayBuffer with .arrayBuffer(), then create a Uint8Array from the buffer.
const blob = new Blob(["hello world"]);
const arr = new Uint8Array(await blob.arrayBuffer());

See Binary Data.